Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P
Physiological goals and you can pharmacology of curcumin
Guide ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the biggest element of the brand new reddish dye out-of turmeric, an enthusiastic Indian spice which is taken from brand new rhizome of the warm bush Curcuma longa, and therefore belongs to the Zingiberaceae family relations. Contained in this chapter, i talk about the pharmacological issues off curcumin and you may talk about this new molecular basics of these affairs. I up coming opinion the newest proven and you can prospective systematic uses out-of curcumin. Curcumin is well known typically since a healing agent, however, the process away from action try detail by detail. The fresh pharmacological outcomes of curcumin appear to be the consequence of a great synergism of systems away from poor biochemical interactions with numerous biological targets when you look at the interconnected signaling pathways. These types of objectives tend to be enzymes such cyclooxygenase, lipoxygenase and you will protein kinases, and you may transcription issues like NF-?B, STAT and Nrf2. Modulation ones particles has an effect on downstream affectors which make the newest antiinflammatory, antioxidant, chemopreventive, anticancer, and you can antimicrobial items out-of curcumin. These outcomes have been examined inside clinical trials out-of curcumin to own problems and inflammatory infection, malignant tumors, Alzheimer state, aerobic disorder, and you can all forms of diabetes. The brand new trials purchased variable doses out of curcuminwith some other wavelengths and period, for the standard achievement you to large dosages out-of curcumin within quantity of grams must obtain therapeutic consequences. Read more
Curcumin: Synthesis, Growing Character during the Discomfort Management and you may Fitness Implications
Publication Chapter Examples of plant-derived pharmaceuticals which have get to be the desire out-of proceeded and you will great research and creativity appeal enjoys, at this point, already been quite scarce. Immediately following years, the last twenty years was characterized by a beneficial 100-fold boost in exactly how many scientific content published annually one is actually from relevance to the entry to curcumin within the biomedicine. Read more
Build, synthesis and you can physical situations away from curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many possible Ukrainsk-bГёrne-datingside pharmacological outcomes and may even has actually therapeutic applications in a lot of disease states, because chatted about in more detail in the previous section. not, the possibility clinical efficacy of curcumin is restricted by the the physicochemical qualities regarding worst drinking water solubility and you can instability, and therefore end up in lowest bioavailability. Prodrugs out-of curcumin offer a way to update of the biopharmaceutical and you may pharmacokinetic characteristics, that can make it exploitation of the pharmacological outcomes of curcumin. Inside chapter, i very first feedback the latest physicochemical and you may pharmacokinetics from curcumin. We following determine the style of curcumin prodrugs having increased h2o solubility and increased chemical substances balance that can easily be translated to 100 % free curcumin up on bioactivation for the vivo. We focus on previous profits here, that have a focus on the structure, synthesis and you may research of prodrugs centered on promoieties and proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric materials eg hyaluronic acidic and you may polyethylene glycol. That it chapter has got the reason behind optimization of your physicochemical and you may biopharmaceutical qualities additionally the physiological issues away from curcumin prodrugs, towards the purpose using of those curcumin derivatives inside the scientific apps. Find out more